Maternity insurance goes to social security center to activate

1.

The materials to be prepared for maternity insurance are as follows:

1. Apply to the personnel department of the unit for the registration form of unit insurance in plicate

2. A of the business license of the enterprise legal person

3. One of organization code certificate

4. A of the tax registration certificate (and provide the local tax computer code)

5. One of bank account opening license

6. The new insured should fill in the application form of maternity insurance and payment, and the register of increase and decrease of fertility personnel in plicate (the new insured should attach the of ID card)

extended data:

the state clearly stipulates that employees should participate in maternity insurance, and the employer should pay maternity insurance premium according to the state regulations, while employees do not pay maternity insurance premium. So as an employee, you have to pay maternity insurance

There are two main benefits of maternity insurance in China. One is maternity allowance, the other is maternity medical treatment. Ministry of human resources and social security "maternity insurance measures (Draft)" from November 20, 2012 open to the public for comments. The draft is clear that the treatment of fertility insurance will no longer be limited to registered residence, and the unit will not pay birth insurance. p>

2. The all-in-one machine covers a small area and is beautiful, but its performance is not as good as that of the split machine. If you are playing games, it is recommended to buy a split machine with independent display. If you are just surfing the Internet and chatting, you can consider B350

3. [help] for DAS
a group of data, when the weight of 2 chambers is 1 / cc, the fitting results of beta = 0.01, T1 / 2beta = 69.315
have reached the boundary of fitting convergence. I feel that this result should not be given, or it should be output with warning

this result is far from the actual situation, which is basically reasonable mathematically and unreasonable pharmacokinetic, I always marvel at the high success rate of Das fitting, but I always feel that it is not appropriate to output the results of Das at the boundary points without warning. Has Das 3.0 been revised

it's a pity that I didn't meet the experts ring my last trip to Shanghai. I'm looking forward to the next opportunity.

gerry.xls (42.5k)
please download the latest version
this problem has been fixed! Look at the results <

book2.xls (36.0k)
two questions:
1. There are six primary parameters in DAS model α< br />B
β
k
Ka
generally speaking, there are only five parameters in the non vascular drug delivery equation. What is the calculation (fitting) formula used by Das? It is not given in the specification.

2 β= 0
t1/2 β= 24447.938
there seems to be something wrong, please advise.

add a small problem:
from the fitting curve of recommended result 2, there is still a certain deviation between the fitting value and the actual value, but in the fitting criterion, R ^ 2 reaches 1. What is the calculation formula of R ^ 2? According to the recommended result 2 given by the software, r = 0.982532146 and R ^ 2 = 0.965369417 were calculated by the simple correlation coefficient (Corel function or Pearson function) α< br />B
β
k
Ka
generally speaking, there are only five parameters in the non vascular drug delivery equation. What is the calculation (fitting) formula used by Das? It is not given in the manual.

please refer to page 118 of pharmacokinetics edited by President Wang Guangji of your university< In the above results, model 2 is recommended:
1 β= 0
t1/2 β= 24447.938
there seems to be something wrong, please advise.

this is really unreasonable, it will be corrected as soon as possible! BTW, which is why DAS is updated frequently. Every time a new problem is solved, the software will be updated. So you need to download the new version on the website frequently

yicaoting write:
from the fitting curve of the recommended result 2, there is still a certain deviation between the fitting value and the actual value, but in the fitting criterion, R ^ 2 reaches 1. What is the formula of R ^ 2? According to the recommended result 2 given by the software, r = 0.982532146 and R ^ 2 = 0.965369417 are calculated by simple correlation coefficient (correl function or Pearson function)< br />R2 = 1 - Σ[( C-C ') 2 / (c-cav) 2]
C' was the fitting concentration, and CAV was the average drug concentration. No time to see the source code, DAS seems to use this formula
I'd like to discuss this with brother yicaoting! The correlation index R2 formula of other curve fitting is the same. Why is R2 = 1 in the pharmacokinetic model- Σ[( C-C’)2/C2]
gerry111 write:
please refer to page 118 of pharmacokinetics edited by President Wang Guangji of your university<

the electronic version of pharmacokinetic (page 118) edited by President Wang Guangji is attached. It seems that there are still no six parameters. Continue to question<

gerry111 write:
this is really unreasonable, it will be corrected as soon as possible! BTW, which is why DAS is updated frequently. Every time a new problem is solved, the software will be updated. So you need to download the new version on the website frequently

in fact, it's normal that the results can't be fitted. Foreign software such as winnonlin and kentica often fail to fit. Das can also consider giving some warnings and tips for the fitting of unsatisfactory data. I'm afraid there are some difficulties in blindly pursuing success.

118. PDF (190.3k)
gerry111 write:
R ^ 2 should be the part of the total variation that can be explained by the model< br />R2 = 1 - Σ[( C-C ') 2 / (c-cav) 2]
C' was the fitting concentration, and CAV was the average drug concentration. No time to see the source code, DAS seems to use this formula
I'd like to discuss this with brother yicaoting! The correlation index R2 formula of other curve fitting is the same. Why is R2 = 1 in the pharmacokinetic model- Σ[( C-C’)2/C2]

in fact, there are some problems in the calculation of model criteria of several domestic softwares. The most serious one is the calculation of AIC value of software, which is totally wrong

as for R, R ^ 2, R, R ^ 2, correlation coefficient, determination coefficient, goodness of fit, discriminant coefficient and so on, many people are confused. One is called correlation coefficient, another is called regression coefficient, and the other is called square of regression coefficient. Chinese and English are not unified, case is not unified, and the whole is a mess

it's OK to give these parameters in the pharmacokinetic software, but it's better to give instructions in the user's Manual of the software, and give the full names of these parameters in Chinese and English, so that users can choose

I appreciate the explanation of R in winnonlin's model criterion. Winnolin only gives a r OBS pre, which is a correlation coefficient directly. In fact, a correlation coefficient is enough in many cases, and the expression coefficient in 3p87 / 97 is very straightforward, which is actually very good. It's mainly about AIC

there is no specific authority for the calculation of these parameters. The calculation formula of SBC (SC) criterion in winnoline and Kinetica is different. Who is right and who is wrong? It seems that we can only refer to the original literature, winnolin's user & # 39; S Guide is very detailed

brother Gerry may have said this formula: R2 = 1- Σ( C-C’)2/ Σ C2, in some books, it's called discriminant coefficient, but I think it's not authoritative. If there is no exact source, we should be cautious about using Chinese names
sorry, I've been very busy these days, so I just answered this question today<

on the first level parameter problem:
in general textbooks, only simple setting does not consider the lag problem, C = a * e (- at) + b * e (- BT) - (a + b) * e (- Kat), when t = 0, C is always 0.
in fact, there is always lag (or lag is 0), so the six first level parameters (a, B, Ka, a, B, K) fitted by DAS. C = a * e (- at) + b * e (- BT) - k * e (- Kat). The lag time can be calculated by calculating a, B, K ring fitting

yicaoting write:
there is no specific authority for the calculation of these parameters. The calculation formula of SBC (SC) criterion in winnoline and Kinetica is different. Who is right and who is wrong? It seems that we can only refer to the original literature, winnolin's user & # 39; S Guide is very detailed

I have checked the data before. Winnoline's SBC criterion calculation formula is correct
SBC = n * ln we + lnn * p p p is the number of parameters, n is the number of points, we is the sum of squares of weighted errors- Σ( C-C’)2/ Σ C2, in some books, it's called discriminant coefficient, but I think it's not authoritative. If there is no exact source, we should be cautious about using Chinese names< br />
R2= 1 - Σ( C-C’)2/ Σ The calculation formula of C2 also appears on page 94 of pharmacokinetics edited by President Wang. I dare not say it's not authoritative
I want to continue to discuss with brother yicaoting why we don't write R2 formula similar to curve fitting here - R2 = 1- Σ[( C-C ') 2 / (c-cav) 2]
gerry111 write:
on the first-order parameter problem:
general textbooks are simply set without considering the lag problem, C = a * e (- at) + b * e (- BT) - (a + B) * e (- Kat), when t = 0, C is always 0.
in fact, there is always lag (or lag is 0), so the six first-order parameters (a, B, Ka, a, B, K) fitted by DAS. C = a * e (- at) + b * e (- BT) - k * e (- Kat). The lag time can be calculated by calculating a, B, K ring fitting

then in C = a * e (- at) + b * e (- BT) - k * e (- Kat), k = - (a + b). I always feel that this k is a little rendant and there is no convincing explanation, especially in the meeting. After all, there are few materials written like this

besides, the problem of time delay can be corrected by writing t as t-tlag and introcing tlag parameter. Here, a k is directly introced. What is the authoritative basis

in the results:
tlag = 0
and
a 334.725
b 241.213
k 200.981
the substitution formula C = a * e (- at) + b * e (- BT) - k * e (- Kat) is also incomprehensible. Or it seems to be wrong. Ask again< br />
gerry111 wrote:
R2= 1 - Σ( C-C’)2/ Σ The calculation formula of C2 also appears on page 94 of pharmacokinetics edited by President Wang. Don't dare to say it's not authoritative: P
I want to continue to discuss with brother yicaoting why we don't write R2 formula similar to curve fitting here - R2 = 1- Σ[( C-C’)2/(C-Cav)2]

R2= 1 - Σ( C-C’)2/ Σ C2 formula does appear in several textbooks, and I think there should be a source. However, there should be some reasons for the so-called standard software like winnolin not to use this criterion. R2= 1 - Σ( C-C’)2/ Σ C2 formula itself reflects the relative size of resial error and actual concentration. However, the Chinese name, ha ha, is very confusing. Wang Guangji's book is called "fitting degree", some textbooks are called "discriminant coefficient", while 3p87 manual, which is widely circulated on the Internet, is also called "certainty coefficient". It is very inconsistent. For R or R ^ 2, I think it is good to use simple correlation coefficient, R2 = 1- Σ( C-C’)2/ Σ C2 makes ordinary users unable to understand or even mislead them into thinking that the sign of correlation coefficient is not very good. Even if this criterion is retained, why does Das abandon the simple correlation coefficient criterion
I'm sorry, I've been away on business these days, so I'll be back tonight

yicaotang write:
then in C = a * e (- at) + b * e (- BT) - k * e (- Kat), k = - (a + b). I always feel that this k is a little rendant, and there is no convincing explanation, especially in the meeting. After all, there are few materials written like this

besides, the problem of time delay can be corrected by writing t as t-tlag and introcing tlag parameter. Here, a k is directly introced. What is the authoritative basis

there are two methods for PK fitting: Micro method and macro method. Micro method is to use parameters such as K12 and K21 for fitting, and macro method is similar to the above formula, using parameters such as a, B and B for fitting. I think it will be more difficult to fit t-tlag into the macro method's fitting formula, which is the reason why micro method is rarely used now. Moreover, it is mathematically equivalent to calculate t-tlag by introcing K and fitting t-tlag directly< In the results:
tlag = 0
and
a 334.725
b 241.213
k 200.981
the substitution formula C = a * e (- at) + b * e (- BT) - k * e (- Kat) is also incomprehensible. Or it seems to be wrong. Ask again

the data of yicaoting is really strange,. There are problems in both results recommended by DAS
the above result is indeed wrong because tlag = 0. In fact, it can be seen from the three data of Abk that according to this result, tlag should be less than 0. In order to avoid this situation, the software forces tlag = 0, so this wrong result is the correct result

4. DCS system_ Information and communication_ Engineering Technology_ Professional information. Scope of work of the bidder the bidder shall provide the necessary hardware, software and services to meet the requirements of this specification. Including (but not limited to) the following contents: 1.2.2.1 according to the unit operation requirements, the provisions of this DCS specification and applicable instrial standards, design and configuration

5.

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oil is a way of survival for many countries, such as Venezuela, Russia, Saudi Arabia and Iran. Oil prices have plummeted, Venezuela's economy has collapsed, and Russia's economy has been depressed by US sanctions. Therefore, US dollar settlement is a powerful weapon for the United States in finance and politics, and the lifeblood of currency war